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Indexed abstracts (on going list)

1) Vascul Pharmacol. 2012 Sep-Oct;57(2-4):91-7. doi: 10.1016/j.vph.2012.05.003. Epub 2012 May 15.From excess adiposity to insulin resistance: the role of free fatty acids.Capurso C, Capurso...

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Unraveling growth hormone part 1

IntroductionI think the hoopla about growth hormone (GH) started in the early 1990s from a study, by Rudman et al., that tested GH injections on old guys (aged 60-80) with low GH levels.  The study...

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Fructose is > glucose Part IV

Since the 1970s the availability and consumption of high fructose corn syrup (HFCS) increased considerably, while sucrose – from sugar cane and beets – decreased by about the same amount.  Overall,...

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Lipopolysaccharide, physical attractiveness, and the complex network of aging

Considering the amount of time and money people spend on how they look, I think it’s reasonable to say that the pursuit of physical attractiveness has become a lifestyle.  Most people want to be good...

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Why stress matters (and the importance of being hot)


Aging is essentially a process of progressively deteriorating adaptation, and as such, should be considered in the context of the stresses to which a person is exposed.  Thus, lifespan can be regarded...

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Body fat comes from carbohydrates?

Consumer books tend to not be factually reliable because the authors of them present data in a selective way to support their overarching message.  Because I’m trusting and take what other people write...

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Stress, adaptation, and diabetes: an integrated picture

A Canadian physiologist, Han Selye, advanced the research on stress and its physiological effects in the body in a series of studies in rats.   He found that chronic stress, regardless of the source,...

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Carbon dioxide, glycation, and the protective effects of fructose

Glycation processes and the potentially protective effects of an intensely active metabolic rate are topics that have been referenced on this blog frequently.  Glycation and cross-linking of molecules...

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Establishing the overarching implications of this blog: health, disease,...

"what children inherit from their parents is not their longevity per se but rather their frailty that is, a set of susceptibilities and risk factors that alter their chances of death at different...

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Saturated fats, unsaturated fats, endotoxin, and implications of the Mani study

Recently a study by Mani et al., was brought to my attention (Mani, Hollis, & Gabler, 2013).  Although I could only get my hands on the study’s abstract (the full paper is not available yet), in...

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Protective inhibition, energy generation, and the neuroprotective effects of...

TerminologyAxon:the slender part of a neuron that conducts electrical impulses away from the neuron’s cell body.Autonomicganglia: a cluster of neurons that provides a junction between the autonomic...

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Are starches safe? Part 1

19thcentury English physician, J.H. Salisbury was free of the shackles of theories, prejudices, and assumptions – the chief one of which was dealing with symptoms as if the symptoms were disease...

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Are starches safe? Part 2

Part 1(SEM image of corn-derived granule in blood after a serving of mueseli)Previously on this blog, it was stated that starches and cereal grains were good food for cows and horses, but not man.  Man...

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The benefits of sugars, shortcomings of starches, and some diametrically...

TerminologyCardiometabolic risk factors: a cluster of risk factors (e.g., high blood glucose levels) that predict a patient’s risk for developing diabetes and cardiovascular disease.Cell energy charge:...

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HFLC dieting, fasting, and some miscellaneous ramblings Part II

Part II know from recent self-experimentation that fasting is not the same as HFLC dieting.  Not even close.Fasting is the intentional abstinence from food, until “true” hunger returns, and is...

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Response to Dr. Paul Jaminet’s rebuttal on fructose

This rebuttalof sorts by Dr. Paul Jaminet was recently brought to my attention through a comment left on my Facebook page.  Danny Roddy was nice enough to lay out the arguments for me point by point....

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Quick commentary on Dr. Lustig’s take on fructose

I’ve recently had the opportunity to skim through Dr. Robert Lustig’s book, Fat Chance.  I haven’t watched his YouTube lecture (and I don’t plan to), which people have used to justify the avoidance of...

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Dr. Ray Peat Fact Check 1: Insulin's Role in Blood Glucose Regulation

"Insulin is important in the regulation of blood sugar, but its importance has been exaggerated because of the diabetes/insulin industry. Insulin itself has been found to account for only about 8% of...

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Dr. Ray Peat Fact Check 2: The Half-Life of Human Fat Tissue is 600 Days?

In the 1940s, some of the toxic effects of fish oil (such as testicular degeneration, softening of the brain, muscle damage, and spontaneous cancer) were found to result from an induced vitamin E...

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Thyroid Hormone, Desaturase Enzymes, and the Implications on Membranes and...

Purely based on physical and chemical considerations, it’s becoming clear that higher membrane saturation indices go hand in hand with longevity and a greater resistance to toxic substances like...

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